| 摘要: |
| 银屑病是一种免疫介导的炎症性皮肤病,涉及角质形成细胞与免疫细胞的相互作用. 根据患者的病情严重程度,银屑病的治疗方法可以分为3种类型,即局部治疗、光疗和全身治疗. 局部治疗主要针对轻中度银屑病患者,但是有皮肤渗透性差、药物皮肤滞留率低等问题；此外,通过口服或肠外给药的全身治疗也存在一些不足之处,包括肝毒性以及需要医疗保健专业人员给药等. 为了解决上述治疗方法存在的问题,研究人员设计了一种基于微针（MNs）的药物输送系统. MNs可以破坏皮肤最外面的角质层,将药物输送到更深的皮肤区域,通过调整针头高度来局部或全身递送抗银屑病药物,而不会产生任何疼痛. 因此,MNs被认为是一种具有应用前景的治疗系统. 文章综述了局部治疗、光疗和全身治疗等治疗方法及其局限性,介绍了MNs的5种类型,即固体MNs、空心MNs、包衣MNs、溶解和水凝胶MNs,并对其进行了展望. |
| 关键词: 银屑病 治疗 微针（MNs） 研究进展 |
| DOI：10.3969/J.ISSN.1000-5137.2024.01.009 |
| 分类号:O 611 |
| 基金项目:国家自然科学基金重大研究计划培育项目（91959105） |
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| Research progress on treatment methods for psoriasis |
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CHANG Qian, YANG Shiping
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College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
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| Abstract: |
| Psoriasis is an immune-mediated inflammatory skin disease involving the interaction between keratinocytes and immune cells. Depending on the severity of the patient's condition, psoriasis treatment can be categorized into three types： topical treatment, phototherapy, and systemic treatment. Topical treatment is primarily targeted at patients with mild to moderate psoriasis. However, it faces challenges such as poor skin permeability and low drug retention rates on the skin. Furthermore, systemic treatments administered orally or through parenteral routes also have some drawbacks, including hepatotoxicity and the need for healthcare professionals for administration. To address the issues associated with existing treatment methods, researchers have designed a microneedle-based drug delivery system. Microneedles （MNs） can disrupt the outermost layer of the skin, allowing drug delivery to deeper skin regions. By adjusting the height of the needles, the system can deliver anti-psoriatic drugs locally or systemically without causing any pain. Therefore, MNs are considered a promising therapeutic system. This article provides a comprehensive review of various psoriasis treatment methods, including topical, phototherapy, and systemic treatments, along with their limitations. It introduces five types of MNs： solid MNs, hollow MNs, coated MNs, dissolving MNs, and hydrogel-forming MNs, offering prospects for their future applications. |
| Key words: psoriasis treatment microneedles（MNs） research progress |
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