| 摘要: |
| 喜树碱是从木本植物喜树（Camptotheca acuminata）中分离获得的一种具有抗癌活性的萜类吲哚生物碱.喜树碱年产量低，价格昂贵，提高喜树碱产量是当前临床亟需解决的问题.概述和比较了当下提高喜树碱产量的一些主流技术和方法，并对喜树碱生物合成基础研究和提高产量策略进行了讨论. |
| 关键词: 喜树碱 植物次生代谢 生物合成 基因工程 |
| DOI：10.3969/J.ISSN.1000-5137.2018.06.017 |
| 分类号:Q812 |
| 基金项目:国家自然科学基金（31570300，31201261）；上海市资源植物功能基因组学重点实验室开放课题（PFGR201801）；上海市协同创新中心项目（ZF1205）；上海市科学技术委员会科研计划项目（17391900600） |
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| Advances on the camptothecin biosynthesis |
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XU Ziyan, PAN Jingxian, QIAN Zhongying, CUI Lijie
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Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China
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| Abstract: |
| Camptothecin is an indole alkaloid with anticancer activity extracted from woodyplant Camptotheca acuminata.The extremely low annual production of camptothecin makes it very expensive,so increasing the yield of camptothecin is an urgent problem to be solved for clinic application.This article reviews some techniques and methods for increasing camptothecin production,and their advantages and disadvantages are compared.Finally,research prospect of camptothecin biosynthesis is also presented. |
| Key words: camptothecin plant secondary metabolism synthetic pathway genetic engineering |
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