| 摘要: |
| 蛋白质S-亚硝基化是一氧化氮（NO）与蛋白质半胱氨酸残基（Cys）共价连接形成S-亚硝基硫醇（-SNO）的过程，被认为是植物中体现NO生物活性的最重要途径.线粒体在依赖S-亚硝基化的NO信号转导中起关键作用.综述了应用蛋白质组学技术鉴定的植物线粒体S-亚硝基化蛋白质的特征，为认识线粒体NO调控网络体系中重要的信号与代谢通路（如光呼吸、三羧酸循环、氧化磷酸化、活性氧分子（ROS）稳态，以及蛋白质加工与周转）提供了线索. |
| 关键词: 植物 线粒体 S-亚硝基化 蛋白质组学 |
| DOI：10.3969/J.ISSN.1000-5137.2018.06.002 |
| 分类号:Q946.1 |
| 基金项目:上海市科学技术委员会科研计划项目（17391900600）；上海市协同创新中心项目（ZF1205） |
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| Advances on plant mitochondrial S-nitrosylation proteomics |
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ZHANG Qiunan1, YU Juanjuan1,2, QIN Zhi1, DAI Shaojun1
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1.Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China;2.Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin 150040, Heilongjiang, China
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| Abstract: |
| Protein S-nitrosylation is the process in which nitric oxide (NO) moiety is covalently attached to protein cysteine (Cys) to form S-nitrosothiol (-SNO).It is considered to be the most important way to reflect the biological activity of NO in plants.Mitochondria play a key role in NO signaling dependent on S-nitrosylation.Proteomics approach has proven to be a very efficient tool for identifying S-nitrosylated proteins in plants.The findings provide insight into important signaling and metabolic pathways in the NO regulatory network of mitochondria (e.g.,photorespiration,tricarboxylic acid cycle,oxidative phosphorylation, reactive oxygen species (ROS) homeostasis,and protein processing and turnover). |
| Key words: plant mitochondrion S-nitrosylation proteomics |
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