| 摘要: |
| 食管癌是人类常见的消化道恶性肿瘤之一,近年来全球食管癌的发病率和死亡率呈上升趋势.我国是食管癌的高发地区,食管癌发病率和死亡率均居世界之首.迄今,食管癌的确切病因尚未完全阐明.建立稳定的、与临床食管癌生物学特性相似的、理想的食管癌动物模型,为研究食管癌的发生、发展、转移机制及其对药物的应答反应等提供了可靠的研究基础,同时有助于抗食管癌药物的筛选和制定合理的临床治疗方案.综合近年来食管癌动物模型的发展,食管癌动物模型的种类,建立模型的方法以及模型评价的进展作了研究介绍. |
| 关键词: 食管癌动物模型 诱发性 移植性 MRI显像 活体成像 |
| DOI： |
| 分类号: |
| 基金项目:上海市科技创新行动计划(11140901400) |
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| Study on establishment of esophageal carcinoma animal models |
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ZHAO Qiang1, WEN Danyi2, SUN Jianhe1
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1.College of Agriculture and Biology Sciences,Shanghai Jiao Tong University;2.Shanghai Chempartner Co.,Ltd.
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| Abstract: |
| Esophageal cancer is one of the common human gastrointestinal malignancies.In recent years,the global incidence of esophageal cancer and its mortality rise.China is the high incidence area of esophageal cancer with the highest morbidity and mortality in the world.However,the exact pathogeny of esophageal cancer has not been fully clarified yet.Thus,it is of significant importance to establish ideal and stable esophageal carcinoma animal models with similar biological characteristics to clinical tumors,which will provide a reliable research basis for the occurrence,development,metastasis and drug responses of esophageal carcinoma,and is also helpful for anti-esophageal cancer drug screening and the development of rational dinical therapeutic treatment.This article provides an overview of the development of esophageal carcinoma animal models in recent years,the classification of esophageal carcinoma animal models,modeling methods and the progress of model evaluation. |
| Key words: esophageal carcinoma animal models induced models transplantation models magnetic resonance imaging in vivo imaging |
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