| 摘要: |
| 合成了一系列未见文献报道的用1,4-二氢吡啶环固定顺式构型的烯啶虫胺类似物(Ia-Ij).初步的杀虫活性测试结果表明:大多数目标化合物在500 mg/L 和 100 mg/L的浓度下,对苜蓿蚜和褐飞虱有高效杀虫活性,其中类似物Ij在4 mg/L时对苜蓿蚜和褐飞虱的致死率都达到100%.分子对接模拟结果显示,标题类似物具有独特的与靶标的结合模式,并初步解释了构效关系. |
| 关键词: 顺式烯啶虫胺类似物 1,4-二氢吡啶 合成 杀虫活性 分子对接模拟 |
| DOI： |
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| Nitenpyram analogues with 1,4-dihydropyridine fixed cis-configuration:synthesis,insecticidal activities and molecular docking studies |
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XUE Sijia, PANG Chuncheng, CHEN Yanxia, LIU Tianyan
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College of Life and Environment Sciences,Shanghai Normal University
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| Abstract: |
| A novel series of Nitenpyram analogues(Ia-Ij) with 1,4-dihydropyridine fixed cis-configuration were designed and synthesized.Preliminary bioassays showed that most of them exhibited good insecticidal activities against Aphis medicagini and Brown rice planthopper at 500 mg/L and 100 mg/L.The analogue Ij afforded the best activity in vitro,that had 100% mortality at 4 mg/L against Brown rice planthopper and Aphis medicagin.In addition,the molecular docking simulations revealed that the structural uniqueness of these analogues may lead to a unique molecular recognition and binding mode,and the results explained the SARs observed in vitro, which shed light on the novel insecticidal mechanism of these novel nitenpyam analogues. |
| Key words: cis-Nitenpyram analogue 1,4-dihydropyridine synthesis insecticidal acvitity molecular docking |
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