| 摘要: |
| 理想的骨再生材料需要具有良好的生物活性和力学强度.前期的研究表明硅磷酸钙（Ca5（PO4）2SiO4，CPS）陶瓷具有良好的生物活性，可诱导骨髓基质干细胞的成骨分化，并在体内可促进新骨的形成.研究了α-氮化硅（α-Si3N4）对CPS生物陶瓷显微结构、抗弯强度、体外磷灰石形成能力及细胞相容性的影响.结果表明：α-Si3N4的添加可在一定程度上提高CPS生物陶瓷的抗弯强度，当其质量分数为1.5%时，Si3N4-CPS陶瓷的抗弯强度为相同温度下纯CPS陶瓷的1.2倍.模拟体液浸泡实验表明：Si3N4-CPS生物陶瓷均具有良好的磷灰石形成能力.CCK-8细胞相容性实验结果表明：Si3N4-CPS生物陶瓷无明显细胞毒性，展示出良好的生物相容性. |
| 关键词: 硅磷酸钙（CPS） α-氮化硅（α-Si3N4） 抗弯强度 磷灰石形成能力 生物相容性 |
| DOI：10.3969/J.ISSN.1000-5137.2021.06.005 |
| 分类号:O611.6 |
| 基金项目:国家重点研发计划（2017YFC1103800） |
|
| Effect of α-Si3N4 on mechanical strength and biological activity of silicocarnotite bioceramic |
|
HE Bo1, WANG Ning2, DENG Fanyan1, FU Lingjie2, NING Congqin1
|
|
1.College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China;2.Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
|
| Abstract: |
| Ideal bone regeneration materials should have good biological activity and mechanical strength. Previous studies have shown that silicocarnotite (Ca5(PO4)2SiO4, CPS) bioceramic has good biological activity, which can induce osteogenic differentiation of bone marrow matrix stem cells and promote the formation of new bones in vivo. This paper investigated the effects of α-silicon nitride (α-Si3N4) on microstructure, bend strength, apatite forming ability and cytocompatibility of CPS bioceramic. The results show that the addition of α-Si3N4 can improve the bending strength of CPS bioceramic to some extent, and when its mass fraction is 1.5%, the bending strength of Si3N4-CPS ceramic is 1.2 times of that of pure CPS ceramic at the same sintering temperature. The simulation body fluid immersion experiment shows that Si3N4-CPS bioceramic has good apatite forming ability. The experimental results of CCK-8 cytocompatibility test show that Si3N4-CPS bioceramic has no obvious cytotoxicity, exhibiting a good biocompatibility. |
| Key words: silicocarnotite(CPS) α-silicon nitride (α-Si3N4) bending strength apatite formation ability biocompatibility |
Editorial Board