| 摘要: |
| 五元环和六元环是许多药物及生物活性分子中的基本结构单元，广泛存在于各种天然产物中.因此，开发高效的合成方法构筑五元/六元环一直是有机合成的热点课题之一.其中，由于过渡金属钌（Ru）催化1，6-烯炔的环化反应具备原子经济、反应条件温和、对官能团兼容性好、产率和选择性高等特点，近年来得到了研究者的广泛青睐.基于反应机理及产物的多样性，简要综述了Ru催化1，6-烯炔环化反应的发展历程和最新进展. |
| 关键词: 钌（Ru） 1，6-烯炔 催化 环化反应 原子经济性 |
| DOI：10.3969/J.ISSN.1000-5137.2020.04.010 |
| 分类号:O6-1 |
| 基金项目:上海师范大学校一般科研项目（SK201909） |
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| Recent progress in ruthenium-catalyzed cyclization of 1, 6-enynes |
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WANG Shanshan, WANG Yongjie, TAN Chunxia, LIU Rui
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College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
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| Abstract: |
| As the fundamental building blocks of medicines and bioactive molecules, five-or six-membered rings could be easily found in a series of natural products.Therefore, the development of methodologies toward the formation of five-or six-membered rings-containing compounds is still a hot topic in synthetic chemistry.Of all significant methods, ruthenium(Ru) -catalyzed 1, 6-enyne cyclization reactions are especially attractive because of the atom-economic fashion,mild reaction conditions,good functional group tolerance and excellent selectivity.This review will focus on the development and recent process of Ru-catalyzed 1, 6-enyne cyclization reactions on the basis of the different mechanisms and product diversity. |
| Key words: ruthenium (Ru) 1, 6-enyne catalysis cyclization atom-economy |
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