| 摘要: |
| 以L-苯丙氨酸甲酯盐酸盐为原料,经中和后,以3,5-二溴水杨醛为催化剂,D-酒石酸为拆分剂,在甲醇溶液中进行不对称转化拆分制备得到D-苯丙氨酸甲酯,拆分后光学纯度>99%,单程收率>80%. |
| 关键词: D-苯丙氨酸甲酯 不对称转换 拆分 |
| DOI： |
| 分类号: |
| 基金项目: |
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| Preparation of D-phenylalanine methyl ester by asymmetric transformation |
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LIAO Benren, XU Jun, YANG Fan
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Department of Chemistry, East China Normal University
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| Abstract: |
| With 3,5-Dibromosalicylaldehyde as racemization catalyst,a general method for preparation of D-Phenylalanine methyl ester was successfully carried out by crystallization with D-tartaric acid in MeOH from L-Phenylalanine methyl ester hydrochloride being neutralized.Under the optimized conditions,the yield of the resolution reached to more than 80% with the optical purity to 99%. |
| Key words: D-phenylalanine methyl ester asymmetric transformation resolution |
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