| 摘要: |
| 肿瘤发病率的逐年上升，严重威胁着人类的健康和生命，在人类与癌症斗争的过程中发展出了许多具有治疗前景的纳米治疗平台.其中，磁性介孔二氧化硅纳米球（MAG-MSNs）被认为是一种具有研究前景的纳米材料.MAG-MSNs具有易制备、低成本、易改性、生物安全性高等特点，提高了材料的性能，使得材料在光热治疗（PTT）肿瘤及化学动力学治疗（CDT）肿瘤等方面具备了一定的应用前景.综述了具有核壳结构MAG-MSNs的结构特点与制备方法，以及其在肿瘤治疗领域中的研究进展. |
| 关键词: 磁性介孔二氧化硅纳米球(MAG-MSNs) 化学动力学疗法(CDT) 光热治疗(PTT) 联合治疗 |
| DOI：10.3969/J.ISSN.1000-5137.2022.05.011 |
| 分类号:O611.3 |
| 基金项目:国家自然科学基金重大研究计划培育项目（91959105） |
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| Synthesis of magnetic mesoporous silica and its application in tumor therapy |
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ZHAO Huifeng1, KANG Ruifang1, ZHU Zixuan1, TIAN Qiwei1,2, YANG Shiping1
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1.College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China;2.Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
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| Abstract: |
| The incidence rate of tumor is increasing year by year, which is a serious threat to human health and life. In the process of human struggle against cancer, many promising nano-therapy platforms have been developed. Among them, magnetic mesoporous silica nanospheres(MAG-MSNs) is considered to be a promising nanomaterial. MAG-MSNs has the characteristics of easy preparation, low cost, easy modification and high biological safety, which improve the properties of the materials, and make the materials have a certain application prospect in photothermal therapy(PTT) and chemical kinetic therapy(CDT) of tumors. Therefore, this paper reviews the structural characteristics and preparation methods of MAG-MSNs with core-shell structure, as well as its research progress in the field of tumor therapy. |
| Key words: magnetic mesoporous silica nanospheres(MAG-MSNs) chemical kinetic therapy(CDT) photothermal therapy(PTT) combined therapy |
