| 摘要: |
| 和传统治疗相比，化学动力学治疗（CDT）被认为是一种低副作用且无创的治疗方法，在众多的治疗方法中脱颖而出.CDT通过金属离子介导的芬顿反应或类芬顿反应，将肿瘤中过表达的过氧化氢（H2O2）分解为剧毒的羟基自由基（·OH），从而杀死肿瘤细胞.近年来，铜基纳米材料在CDT中蓬勃发展，极大地提高了CDT的效率.因此，基于铜基纳米材料，归纳了通过调节肿瘤微环境来增强CDT以及其他疗法的协同治疗，为开发新型的类芬顿试剂提供了思路借鉴. |
| 关键词: 化学动力学治疗（CDT） 芬顿/类芬顿反应 铜基纳米材料 肿瘤微环境 协同治疗 |
| DOI：10.3969/J.ISSN.1000-5137.2021.04.010 |
| 分类号:O614.22 |
| 基金项目:国家自然科学基金重大研究计划培育项目（91959105） |
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| Recent advances of copper-based nanomaterials for enhancing chemodynamic therapy |
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CHENG Yuying, ZHOU Xuesu, YAN Ge, TIAN Qiwei, YANG Shiping
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College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
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| Abstract: |
| Compared with traditional treatments, chemodynamic therapy (CDT) is considered as a non-invasive treatment method with low side effects, which stands out among many treatment methods. CDT uses metal ion-mediated Fenton or Fentonlike reactions to decompose the highly expressed hydrogen peroxide(H2O2) in tumors into highly toxic hydroxyl radicals(·OH), thereby killing tumor cells.In recent years, copper-based nanomaterials have flourished in CDT, greatly improving the efficiency of CDT. Therefore, based on copper-based nanomaterials, this article summarizes the enhancement of CDT by modulating the tumor microenvironment and the synergistic treatment with other therapies, which provide a reference for the development of novel Fenton-like reagents. |
| Key words: chemodynamic therapy(CDT) Fenton/Fenton-like reaction copper-based nanomaterials tumor microenvironment synergistic therapy |
