| 摘要: |
| 为全面理解载脂蛋白B mRNA（ApoB mRNA）编辑酶催化多肽-1（APOBEC1）的作用机制，介绍了APOBEC1和ApoB mRNA的蛋白及核酸序列，总结并绘制了APOBEC1与不同的辅助蛋白的结合模型，阐述了APOBEC1催化ApoB mRNA第6 666位的胞嘧啶（C6666）脱氨基化分子机制.列举了啮齿动物APOBEC1抑制多种逆转录病毒的研究报道，介绍了兔源APOBEC1结合人类免疫缺陷病毒1（HIV-1）的病毒粒子并编辑病毒基因组的机理.同时介绍了APOBEC1通过编辑胞嘧啶或与AU富集元件（ARE）结合来调控癌症等疾病相关的细胞因子表达. |
| 关键词: 载脂蛋白B mRNA（ApoB mRNA） 载脂蛋白B mRNA编辑酶催化多肽-1（APOBEC1） 胞嘧啶脱氨基化 |
| DOI：10.3969/J.ISSN.1000-5137.2020.02.012 |
| 分类号:Q-71 |
| 基金项目:国家自然科学基金（21778065；91753119） |
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| Research advances on cytosine deaminase APOBEC1 |
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ZHOU Binghan1,2, YAN Xiaoxuan2, LAN Wenxian2, WANG Chunxi2, CAO Chunyang2
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1.College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China;2.State Key Lab of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
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| Abstract: |
| In order to fully understand the mechanisms of Apolipoprotein B mRNA(ApoB mRNA)editing enzyme catalytic polypeptide-1(APOBEC1), this review introduced the amino acid and nucleic acid sequences of APOBEC1 and ApoB mRNA, summarized and mapped the binding models of APOBEC1 with different cofactors to explain the molecular mechanism of APOBEC1 catalyzing the deamination of the 6666 C of ApoB mRNA(C6666). The researches of rodent APOBEC1 inhibiting multiple retroviruses were exemplified here, and the related mechanisms of rabbit APOBEC1 binding to human immunodeficiency virus type 1(HIV-1)and editing the viral genome were discussed.This review also introduced APOBEC1 regulating the expression of cytokines related to cancers and other diseases by deamination editing or combining with AU-rich element (ARE)of RNAs. |
| Key words: apolipoprotein B mRNA(ApoB mRNA) ApoB mRNA editing enzyme catalytic polypeptide-1(APOBEC1) cytidine deamination |
