| 摘要: |
| 磁共振成像（MRI）技术是常见的临床医学影像学的检测手段之一.在临床诊断中使用最多的是纵向弛豫（T1）造影剂：马根维显（Gd-DTPA）.自其正式商用化后，人们对钆基造影剂进行了大量研究.文章介绍了钆基无机纳米粒子（Gd IONPs）造影剂的作用原理，阐述了无机纳米粒子的形貌、尺寸、表面修饰、氧空位等因素的影响，并对Gd IONPs造影剂的设计做了展望. |
| 关键词: 钆基造影剂 磁共振成像(MRI) 纵向弛豫率(r1) 无机纳米粒子 |
| DOI：10.3969/J.ISSN.1000-5137.2022.05.014 |
| 分类号:O614.33 |
| 基金项目:国家自然科学基金（21877080） |
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| Research progress in the design of gadolinium-based inorganic nanoparticles for magnetic resonance contrast agents |
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ZHAO Shuo, ZHOU Zhiguo
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College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
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| Abstract: |
| Magnetic resonance imaging(MRI) is one of the common detection methods in clinical medical imaging. The most commonly used longitudinal relaxation (T1) contrast agent in clinical diagnosis is Gadopentetate Dimeglumine(Gd-DTPA). Since their commercialization, gadolinium-based contrast agents have been studied extensively. This paper introduces the working principle of gadolinium-based inorganic nanoparticle(Gd IONPs) contrast agents, expounds the influence of the morphology, size, surface modification, oxygen vacancy of the inorganic nanoparticles, and looks forward to the design of gadolinium-based inorganic nanoparticle contrast agents. |
| Key words: gadolinium-based contrast agent magnetic resonance imaging(MRI) longitudinal relaxation rate(r1) inorganic nanoparticles |
