| 摘要: |
| 体内金属离子的检测常采用磁共振成像（MRI）.MRI灵敏度较低，需要造影剂来提高检测的精确度.目前临床上用的造影剂主要是Gd3+螯合物.综述了基于Gd3+造影剂的生物体内金属离子检测的研究进展. |
| 关键词: 磁共振成像(MRI) 造影剂 Gd3+ 生物传感器 |
| DOI：10.3969/J.ISSN.1000-5137.2018.01.014 |
| 分类号: |
| 基金项目:国家自然科学基金（21601124，21671135） |
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| Advances in application of Gd3+ contrast agent for in vivo detection of metal ions |
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Li Jiaojiao, Tian Qiwei, Yang Shiping
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College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China
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| Abstract: |
| In the life system,metal ions are the important elements for tissue growth and development.The content of the metal ions is closely related to the balance of the internal environment.If the in vivo concentrations of metal ions are out of balance,it will be easy to cause diseases.Therefore,it is very important to assess and understand the concentration changes of in vivo metal ions for the diagnosis of diseases.Due to its deep tissue penetration,high spatial resolution,no damage,no invasion,and ability to track three-dimensional dynamic imaging,MRI is widely used for the detection of the in vivo metal ions.Normally,MRI contrasts are required to improve the accuracy of metal ion detection by reason of the low sensitivity of MRI.At present,the contrast agents used in the clinical detection of in vivo ions are mainly Gd3+ chelates.Thus,we will introduce the recent advances of Gd3+ contrast agents for in vivo detection of metal ions in this review. |
| Key words: magnetic resonance imaging(MRI) contrast agent Gd3+ biosensor |
