| 摘要: |
| 通过纳米载体运输药物，并在特定的组织释放药物已经成为生物医学的热门研究之一.由于实体肿瘤的高通透性和滞留效应，纳米颗粒容易进入肿瘤细胞，并在肿瘤细胞中富集，因此以纳米粒子为载体加载药物并在目标细胞或组织释放药物可以提高靶部位的药物浓度，增加药效，降低药物对生物体全身的毒副作用.通常，载药的纳米粒子释放药物的方式有两种，即扩散型释放与侵袭型释放.而刺激纳米粒子释放药物的方式多种多样，包括pH响应、酶响应、光响应、磁响应以及超声波响应等.主要介绍了多功能纳米粒子的载药原理及其研究现状. |
| 关键词: 纳米载体 药物运输 生物医学 |
| DOI：10.3969/J.ISSN.1000-5137.2017.06.002 |
| 分类号:O633.4 |
| 基金项目:国家自然科学基金（21571130） |
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| Nano-carriers and their drug release |
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Deng Guang, Wang Xiyou, Zhou Zhiguo, Yang Shiping
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College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China
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| Abstract: |
| One of the hottest fields in biomedicine research is to encapsulate drugs and release them in particular organs by using nano-platform.Because nanoparticles can enter most cancer cells easily and accumulate inside the cells,drug-loaded nanoparticles with targeting modification can help to increase the drug concentration in lesion position,enhancing the drug effects and reducing the toxicity.In general,drug-loaded nanoparticles release drugs by diffusion or erosion.There are many ways to stimulate the release of drugs from nanoparticles,including pH,enzyme,light,magnetism,and ultrasound responses.This article reviews the principle and recent advances of drug-loaded nanoparticles. |
| Key words: nano-carriers drug delivery biomedicinee |
