| 摘要: |
| 以氯化铜、1-苯基-3-甲基-4-苯甲酰基-5-吡唑啉酮和2,6-吡啶二羧酸为原料,制备了一个新型的三元配合物,通过元素分析、红外光谱、紫外光谱、X射线粉末衍射、热重-差热分析、光电子能谱分析及TEM等手段对配合物进行了表征,确定了配合物的化学组成可能是Na［Cu(PMBP)(PDA)］.抗菌实验结果表明,配合物对大肠杆菌、金黄色葡萄球菌具一定的抑制作用.采用紫外光谱法和荧光光谱法初步研究了配合物与CT-DNA的作用方式,结果表明:配合物可能是以插入模式与DNA结合的. |
| 关键词: 铜 配合物 抗菌 DNA |
| DOI： |
| 分类号: |
| 基金项目:上海师范大学重点学科(DEL124,DZL123):上海师范大学一般科研项目(SK201235,SK201048) |
|
| Synthesis,characterization and properties of some rare earth complexes with pyrazolone and 2,6-pyridinecarboxylic acid |
|
CHEN Jing1, CHENG Ningning1, YU Hui2, XU Dongfang1, LIN Jingrong1, HE Qizhuang1
|
|
1.College of Life and Environmental Sciences,Shanghai Normal University;2.Interdisciplinary Research Centre,Shanghai Normal University
|
| Abstract: |
| A new solid ternary complex of copper with 1-phenyl-3-methyl-4-acetyl-pyrazolone-5 and 2,6-pyridinecarboxylic acid Na［Cu(PMBP)(PDA］ has been synthesized and characterized by elemental analysis,FT-IR,UV-Vis,XRD,TG-DTA,and XPS.The antibacterial test indicated that the complex exhibited moderate antibacterial ability against Escherichia coli and Staphylococcus aureus.The interactions of the complex with calf thymus DNA (CT DNA)was investigated by employing florescence spectroscopic studies and ultraviolet spectrum spectrom etries.The results indicated that the complex can intercalate between DNA base pairs. |
| Key words: copper complex antibacterial DNA |
